0Definition:Massive proteinuria >3.5g/day
First protein to be excreted is albumin-->transferrin-->vitamin D binding protein-->thyroglobulin-->protein c and s-->globulin
1.Minimal change disease:
Sudden onset selective proteinuria
Age:5-15yrs
Prognosis :excellent
Kidney biopy: light microscopy-no findings
Fluorescent microscopy-no findings
Electron microscopy-podocytopathy(loss of foot processes of podocytes)
2.Membranous glomerulonephritis
Etiology:primary-Antiphopholipid A2antibody
Secondary-infections like Hep B,HIV,Hep C,leprosy
Autoimmune diseases
drugs
Malignancies
Kidney biopsy:light microscopy-GBM thickening
Fluorescent microscopy-subepithelial granular deposits
Electron microscopy-subepithelial deposits with podocytopathy
